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. 2022 May 5;17(5):e0266137. doi: 10.1371/journal.pone.0266137

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© 2022 Genç et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — CD3+CD4+ T lymphocyte proliferation rate was significantly high in SS mice (Group 2) compared to the control group (Group 1) (p<0.001). The intraperitoneally injected DFMSCs (Group 3a) significantly decreased CD3+CD4+ T lymphocyte proliferation rate compared to Group 2 (p<0.01). Submandibular and lacrimal injections of DFMSCs tended to decrease the lymphoproliferative responses of CD3+CD4+ T lymphocytes compared to Group 2, but no significant difference was observed (p>0.05). CD19+ B lymphocyte proliferation rate was significantly high in SS mice (Group 2) compared to the control group (Group 1) (p<0.001). The intraperitoneal injection of DFMSCs (Group 3a) significantly decreased CD19+ B lymphocyte proliferation rate compared to Group 2 (p<0.01). Submandibular and lacrimal injections of DFMSCs did not significantly change the lymphoproliferative responses of CD19+ B lymphocytes compared to Group 2 (p>0.05).