Skip to main content
. 2022 May 5;17(5):e0266137. doi: 10.1371/journal.pone.0266137

Fig 3. Cytokine secreting CD4+T lymphocyte ratio.

Fig 3

The intraperitoneal injection of DFMSCs significantly reduced the CD4+IFN-γ+ T cell ratio compared to Group 2 (p<0.001). The submandibular and lacrimal injections of DFMSCs tended to decrease the CD4+IFN-γ+ T cell ratio (6.2±0.4% and 6.7±0.6%) in the splenocytes, but no significant difference was observed when compared with Group 2 (p>0.05 and p>0.05). The intraperitoneal and submandibular injections of DFMSCs significantly reduced the CD4+IL-17+ T cell ratio compared to Group 2 (p<0.001 and p<0.005, respectively). The lacrimal injected DFMSCs tended to decrease CD4+IL-17+ T cell ratio in the splenocytes, but no significant difference was observed when compared with Group 2 (p>0.05). The intraperitoneal injection of DFMSCs significantly increased CD4+IL-10+ T cell ratio in Group 3a compared to Group 2 (p<0.01), but no significant difference was observed in submandibular and lacrimal injected DFMSCs when compared with Group 2 (p>0.05 and p>0.05, respectively).