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. 2022 May 5;17(5):e0266137. doi: 10.1371/journal.pone.0266137

Fig 4. The secreted cytokine levels in the culture supernatant of splenocytes, saliva, and tears.

Fig 4

(a) The cytokine levels in the culture supernatants of splenocytes. Intraperitoneal injection of DFMSCs significantly increased IL-10 levels in Group 3a (p<0.01), and significantly decreased the secreted IFN-γ and IL-17 levels compared to Group 2 (p<0.01 and p<0.01, respectively). Submandibular and lacrimal injections of DFMSCs did not significantly change the secreted IFN-γ (p>0.05 and p>0.05, respectively), IL-17 (p>0.05 and p>0.05, respectively), and IL-10 levels when compared with Group 2 (p>0.05 and p>0.05, respectively). (b) The cytokine levels in saliva. Intraperitoneal injection of DFMSCs significantly increased IL-10 levels in Group 3a (p<0.05), and significantly decreased the secreted IFN-γ and IL-17 levels compared to Group 2 (p<0.05 and p<0.05, respectively). Submandibular injection of DFMSCs significantly decreased the secreted IFN-γ and IL-17 levels in the saliva compared to Group 2 (p<0.01 and p<0.05, respectively). Submandibular injection of DFMSCs significantly increased IL-10 levels in the saliva compared to Group 2 (p<0.05). (c) The cytokine levels in tears. Intraperitoneal injection of DFMSCs significantly increased IL-10 levels in Group 3a (p<0.05), and significantly decreased the secreted IFN-γ and IL-17 levels compared to Group 2 (p<0.01 and p<0.01, respectively). Lacrimal injection of DFMSCs significantly decreased the secreted IFN-γ and IL-17 levels in the tears compared to Group 2 (p<0.05 and p<0.01, respectively). Lacrimal injection of DFMSCs significantly increased IL-10 levels in the saliva compared to Group 2 (p<0.05).