Table 1. Characteristics of study population.
| Number of subjects | 18 | |
| Age in years a | 32± 10 | |
| Female, n (%) | 10 (56) | |
| Genotype, n (%) F508del/F508del | 9 (50) | |
| Race, ethnicity, n (%) | ||
| Non-Hispanic white | 18 (100) | |
| CFQ-R respiratory score a | ||
| Pre-treatment | 62.6 ± 14.4 | |
| Post-treatment | 66.7 ± 18.1 | |
| FEV1 (% predicted) ab | ||
| Pre-treatment | 57± 17 | |
| Post-treatment | 61 ± 18 | |
| Change in absolute ppFEV1 (range) | -1.8 to 11 | |
| CRP (mg/dL) ac | ||
| Pre-treatment | 0.48 ± 0.54 | |
| Post-treatment | 0.92 ± 1.1 | |
| Neutrophil Elastase from Sputum a (μg/mL) | ||
| Pre-treatment | 10.12 ± 12.44 | |
| Post-treatment | 14.29 ± 18.70 | |
| CFRD, n (%) | 7 (39) | |
| Microbiology at study enrollment, n (%) | ||
| P. aeruginosa only | 10 (56) | |
| P. aeruginosa and S. aureus | 7 (39) | |
| Pseudomonas and other (A.baumanii, A. xylosoxidans, E. coli) | 3 (17) | |
| Bacteria density a (CFU/mL) | ||
| Total Bacterial density- Pre-treatment b | 8.8 E7 ± 9.9E7 | |
| Total Bacterial density- Post-treatment | 6.0E7 ± 1.4E8 | |
| P. aeruginosa pre-treatment | 8.6E7 ± 1.1E8 | |
| P. aeruginosa post-treatment | 5.9E7 ± 1.5E8 | |
| S. aureus pre-treatment | 4.0E7 ± 4.6E7 | |
| S. aureus post-treatment | 2.0E7 ± 3.4E7 |
a All values are depicted as means ± SD, unless otherwise noted.
b p< 0.05 for pre vs post comparison, paired t-test.
c p<0.05 for pre vs post comparison on untransformed data using Wilcoxon signed rank test.