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. 2022 Apr 21;12:843157. doi: 10.3389/fonc.2022.843157

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Copyright © 2022 Timani, Rezaei, Whitmill, Liu and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Tip110 knockout on gene expression in several NF-κB-related signaling pathways. Affymetrix Transcriptome Analysis Console software provided a list of pathways found in WIKI Pathways Beta that were most perturbed by Tip110 loss. This information was used to construct bar graphs depicting the fold change of some of the associated genes. Genes associated with MAPK (A), TNF-α-NF-κB (B), p53 (C), signaling pathways were included. (D) Data from Affymetrix microarray analysis of wild-type and Tip110 knockout-mouse embryonic stem cell RNA revealed the fold changes of genes in these networks. Genes are shown in red when upregulated and in green when downregulated. Pathway information was adapted from MAPK and other signaling pathways depicted in WIKI Pathways Beta.