Table 3.

Multiple Cox regression model stratified by region on death in ICD patients including single variables of interest

	HR	95% CI	P-value
Age (years)	1.03	1.01–1.05	<0.01
BMI (kg/m2)	0.97	0.94–1.00	0.03
Chronic obstructive pulmonary disease (yes vs. no)	2.33	1.71–3.19	<0.01
eGFR	0.99	0.99–1.00	0.07
Haemoglobin (g/dL)	0.88	0.81–0.96	<0.01
Loop diuretic (yes vs. no)	1.37	0.95–1.99	0.09
LVEF (%)	0.95	0.93–0.97	<0.01
NYHA (Class III or IV vs. Class I or II)	1.65	1.25–2.20	<0.01
PAD (yes vs. no)	1.56	1.10–2.21	0.01
Sex (male vs. female)	1.43	0.98–2.10	0.06
Sodium (mmol/L)	0.93	0.90–0.97	<0.01
Adjusting for the variables shown above and stratifying by region, we observe the following results for each parameter individually
QRSd (ms)	1.01	1.00–1.01	0.09
Heart rate (b.p.m.)	1.01	0.10–1.02	0.15
QTc	1.00	1.00–1.01	0.08
Q_ant (yes vs. no)	0.40	0.21–0.76	<0.01
fQRS_lat (yes vs. no)	1.50	1.12–2.00	<0.01
Q_tot (yes vs. no)	0.54	0.35–0.84	<0.01
Atrial fibrillation (yes vs. no)	1.42	1.07–1.90	0.02
QRS120 (yes vs. no)	1.30	0.98–1.73	0.07
IVCD (yes vs. no)	1.28	0.94–1.76	0.12
QTc 450/470 (yes vs. no)	1.20	0.89–1.63	0.23
Sinus rhythm (yes vs. no)	0.83	0.58–1.18	0.30

n = 1444, statistically significant results presented in bold.

95% CI, 95% confidence interval; BMI, body mass index; eGFR, estimated glomerular filtration rate; fQRS, QRS-complex fragmentation; HR, hazard ratio; ICD, implantable cardioverter-defibrillator; IVCD, non-specific intraventricular conduction delay; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; PAD, peripheral artery disease; Q, pathological Q wave; QRS120, QRS duration ≥120 ms (1) or less 0; QRSd, QRS duration; QTc 450/470, QTc ≥450 ms in male and ≥470 ms in female (1) or less 0; QTc, QT-interval corrected by Framingham’s formula.