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. 2021 Nov 30;37(2):89–111. doi: 10.1093/mutage/geab040

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© The Author(s) 2021. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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3Dskin RSMN results for Nona-2 trans- 6-cis-dienal (CAS# 557-48-2): (A) 48-hour treatment and (B) 72-hour treatment condition. The long-dashed black line shows the lab-specific 95%-quantile of the mean of the historical control range for the MNBN data, and the thresholds for excessive cytotoxicity (40%) are shown by the black dotted line. A red asterisk indicates a statistically significant increase in % MNBN vs. the SC (Fisher’s exact test; P < .05). Error bars shown depict the standard error of the mean.