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3Dskin RSMN results for Cadinene (CAS#29350-73-0): (A) 48-hour treatment and (B) 72-hour treatment condition. The long-dashed black line shows the lab-specific 95%-quantile of the mean of the historical control range for the MNBN data, and the cutoff for excessive cytotoxicity (40%) is shown by the black dotted line. A red asterisk indicates a statistically significant increase in % MNBN vs. the SC (Fisher’s exact test; P < .05). Error bars shown depict the standard error of the mean.
