Table 1.
Material | CAS # | In vitro MNT | 3D Skin MNT | In vivo MNT |
---|---|---|---|---|
sec-Butyl ethyl ether | 2679-87-0 | + | - | - |
Cadinene | 29350-73-0 | +a | - | |
2,3-Dihydro-1,1-dimethyl-1H-indene-ar-propanal | 300371-33-9 | Equivocal | - | |
1,5-Dimethylbicyclo[3.2.1]octan-8-one-oxime | 75147-23-8 | + | - | - |
2,2ʹ-(Dithiodimethylene)difuran | 4437-20-1 | + | - | - |
Ethyl formate | 109-94-4 | + | - | - |
2-Ethyl-1,3,3-trimethyl-2-norbornanol | 18368-91-7 | - | - | - |
Furfuryl thioacetate | 13678-68-7 | + | - | - |
Isobornyl methyl ether | 5331-32-8 | Equivocal | - | -for read-acrossb |
Lauric Aldehyde | 112-54-9 | + | - | - |
p-Methoxy cinnamaldehyde | 1963-36-6 | + | - | - |
6-Methoxy-2,6-dimethylheptan-1-al | 62439-41-2 | + | - | - |
2-Methyl-2-pentenal | 623-36-9 | + | - | - |
Methyl beta-phenylglycidate | 37161-74-3 | +∗ | - | - |
Nona-2 trans- 6-cis-dienal | 557-48-2 | + | - | - |
2-Octenoic acid, 4-ethyl-, (2Z) | 60308-75-0 | + | - | - |
2-Octen-4-one | 4643-27-0 | + | - | - |
4-Phenyl-3-buten-2-ol | 17488-65-2 | + | - | - |
5-Phenylhex-3-en-2-one | 60405-50-7 | Equivocal | - | -for read-acrossc |
4-Thujanol | 546-79-2 | + | - | - |
3,3,5-Trimethylcyclohexaneacetic acid | 3213-73-8 | + | - | - |
Veratraldehyde | 120-14-9 | + | - | - |
Results did not meet all criteria for a positive.
Read-across analogue is 1-ethyl-3-methoxytricyclo[2.2.1.02,6]heptane (CAS # 31996-78-8).
Read-across analogue is 4-Phenyl-3-buten-2-one (CAS#122-57-6).