Fig 2. Drug-food compound similarity.

(A) Number of hits retrieved from each split-sets model. (B) 200 drug-food pairs predicted as ‘match’ at the probability threshold of >0.5. The drugs are arranged according to their therapeutic class and food compounds according to their food source. The highlighted colored links represent the case examples in the five author defined groups (details in the text). (C) Group4-probable lead example taken up for experimental validation. The food compound 5-methoxysalicylic acid was a hit with the drug triflusal which has 4 known targets. We validated the inhibitory activity of triflusal and 5-methoxysalicylic acid against the target PTGS1 (also known as Cox-1).