Table 3.
The characteristics of ferroptosis-related transport protein associated with malignant brain tumors.
| Gene symbol | Alias | Protein name | Subcellular | Substrates | Related Brain Cancer |
|---|---|---|---|---|---|
| SLC7A11 | xCT | Cystine/glutamate transporter |
Plasma membrane | Cystine, Glutamate | Glioblastoma, Neuroblastoma |
| SLC3A2 | 4F2hc | 4F2 cell-surface antigen heavy chain |
Lysosome, Plasma membrane | L-type amino | Glioblastoma, Neuroblastoma |
| SLC1A5 | ASCT2 | Neutral amino acid transporter B (0) |
Plasma membrane | Glutamine | Glioblastoma |
| SLC38A1 | SNAT1 | Sodium-coupled neutral amino acid transporter 1 | Plasma membrane | Glutamine | Glioblastoma |
| SLC11A2 | DMT1 | Natural resistance associated macrophage protein 2 |
Plasma membrane, Endosome, Mitochondrion |
Fe2+ | Glioblastoma |
| SLC40A1 | Fpn1 | Solute carrier family 40-member 1 | Plasma membrane | Fe2+ | Glioblastoma, Neuroblastoma |
| SLC39A14 | ZIP14 | Metal cation symporter ZIP14 | Plasma membrane | Mn2+, Fe2+, Zn2+ | |
| TFR1 | TFRC | Transferrin receptor protein 1 | Plasma membrane | Fe3+ | Glioblastoma, Neuroblastoma |