Fig. 1.

Study overview and description of patient cohorts. (A) A clinical cohort of meningiomas were evaluated for patient demographics, histologic and molecular features, preoperative and postoperative tumor volume, and clinical follow-up including recurrence and death. (B) Description of 950 meningiomas analyzed. The discovery cohort consisted of 527 tumor samples from unique patients, with 338 primary tumors without history of treatment or prior radiotherapy. Validation was performed on 2 independent cohorts of 117 patients and 55 patients. Copy number was additionally derived from a molecular cohort of publicly available methylation and RNAseq datasets.