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. 2021 Sep 11;24(5):796–808. doi: 10.1093/neuonc/noab213

Fig. 4.

Fig. 4

Evaluation of Integrated Grade as a predictor of meningioma behavior. (A, B) Progression-free survival of 338 patients with primary meningiomas after GTR, stratified by (A) WHO grade or (B) Integrated Grade. (C, D) Progression-free survival stratified by Integrated Grade among (C) WHO grade I and (D) WHO grade II tumors. (E) Progression-free survival of discrepantly graded meningiomas (P < .01, log-rank test). (F) Progression-free survival among patients with brain invasion on histopathologic analysis, stratified by Integrated Grade 1 vs Integrated Grades 2-3. (G) Time-dependent area under the curve (AUC) of a ROC for Integrated Grade and WHO grade (Integrated Grade: 5-year AUC 0.823, 95% CI 0.724-0.91 vs WHO grade: 5-year AUC 0.632, 95% CI 0.521-0.737). (H) Time-dependent average precision for Integrated Grade and WHO grade (Integrated Grade: 5-year AP 0.781, 95% CI 0.485-1.0; vs WHO grade: 5-year AP 0.405, 95% CI 0.258-0.586). (I) Brier prediction curve for progression-free survival comparing Integrated Grade to WHO grade in the 338 patients (Brier score: 0.098 vs 0.180). Abbreviation: GTR, gross total resection.