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. 2022 Apr 21;12:841418. doi: 10.3389/fonc.2022.841418

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Copyright © 2022 Kram, Prokop, Haller, Gempt, Wu, Schmidt-Graf, Schlegel, Conrad and Liesche-Starnecker

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Co-expression of ferroptosis-associated markers with GFAP and Iba1. Given are the numbers of ACSL4⁺ or GPX4⁺ cells of GFAP⁺ or Iba1⁺ cells. The dots indicate the amounts of each patient in the primary and relapse tumor. (A) The number of ACSL4⁺/GFAP⁺ cells increases significantly in the relapse. (B) The amount of ACSL4⁺/Iba1⁺ cells increases significantly in the relapse. (C) The number of GPX4⁺/GFAP⁺ cells decreases significantly in the relapse. (D) The amount of GPX4⁺/Iba1⁺ cells decreases significantly in the relapse.