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. 2022 Apr 21;12:841418. doi: 10.3389/fonc.2022.841418

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Copyright © 2022 Kram, Prokop, Haller, Gempt, Wu, Schmidt-Graf, Schlegel, Conrad and Liesche-Starnecker

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kaplan-Meier survival curves. Starting point for measurement of survival time was the time at recurrent confirmation. The p-value describes a possible association between enzyme expression and OS. (A) Patients whose ACSL4 expression increased by more than 2.00 IRS points had a worse outcome, although. (B) GPX4 cutpoint is at -3.67. Patients with a higher pronounced decrease in GPX4 expression had a slightly better outcome. (C) FSP1 cutpoint is at 0.67. There is no relevant association. (D) ALDH1A3 cutpoint is at 2.00. Patients with a higher increase had a worse outcome.