Table 3.
Multivariable Analysis of Clinical and Molecular Prognostic Factors
| Multivariable Model | ||||||
|---|---|---|---|---|---|---|
| PFS | OS | |||||
| Factor | HR | CI 95% | p-value | HR | CI 95% | p-value |
| Age | 1.032 | 0.994–1.071 | 0.101 | 1.050 | 0.999–1.103 | 0.056 |
| Contrast enhancement | 1.260 | 0.393–4.039 | 0.698 | 1.838 | 0.460–7.337 | 0.389 |
| GTR | 0.248 | 0.067–0.920 | 0.037 | 0.194 | 0.045–0.842 | 0.029 |
| EGFR amplification | 7.572 | 1.137–50.429 | 0.036 | 17.308 | 1.915–156.471 | 0.011 |
| pTERT mutation | 8.774 | 1.768–43.548 | 0.008 | 9.085 | 1.569–52.596 | 0.014 |
| MGMTp methylation | 2.024 | 0.511–8.013 | 0.315 | 0.775 | 0.166–3.621 | 0.746 |
| Adjuvant treatment | 0.703 | 0.219–2.263 | 0.555 | 0.446 | 0.074–2.679 | 0.377 |
GTR: gross total resection (for all cases with molecular alterations included in the table, a volumetric estimation of the extent of resection is provided. GTR is defined as 100% tumor volume resection).