TABLE 2.
Adjusted HRs and 95% CIs for associations of red meat intake with risk of CRC by age in the BWHS1
| Participant age, y | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| All | ≥50 | <50 | |||||||
| Cases, n | Person-y | HR (95% CI)2 | Cases, n | Person-y | HR (95% CI)2 | Cases, n | Person-y | HR (95% CI)2 | |
| Total red meat, servings/wk | |||||||||
| 0–<2 (0–<170 g/wk) | 187 | 375,098 | 1.00 | 144 | 182,795 | 1.00 | 43 | 192,303 | 1.00 |
| 2–<4 (170–<340 g/wk) | 192 | 371,319 | 1.14 (0.92, 1.41) | 150 | 166,094 | 1.25 (0.98, 1.60) | 42 | 205,225 | 0.84 (0.53, 1.32) |
| ≥4 (≥340 g/wk) | 185 | 369,760 | 1.25 (0.96, 1.63) | 126 | 138,260 | 1.31 (0.96, 1.79) | 59 | 231,500 | 1.08 (0.65, 1.79) |
| Ptrend3 | 0.1 | 0.1 | 0.6 | ||||||
| Continuous, per 100 g/d | 1.26 (0.94, 1.69) | 1.38 (0.98, 1.94) | 0.99 (0.56, 1.75) | ||||||
| Processed meat, servings/wk | |||||||||
| 0–<0.5 (0–<42.5 g/wk) | 190 | 372,769 | 1.00 | 147 | 170,967 | 1.00 | 43 | 201,802 | 1.00 |
| 0.5–<1 (42.5–<85 g/wk) | 163 | 292,516 | 1.16 (0.93, 1.45) | 124 | 133,648 | 1.19 (0.92, 1.53) | 39 | 158,868 | 1.08 (0.69, 1.70) |
| ≥1 (≥85 g/wk) | 211 | 450,891 | 1.02 (0.81, 1.29) | 149 | 182,533 | 1.04 (0.79, 1.36) | 62 | 268,358 | 0.96 (0.61, 1.52) |
| Ptrend3 | 0.9 | 0.9 | 0.7 | ||||||
| Continuous (per 50 g/d) | 1.02 (0.83, 1.26) | 1.06 (0.83, 1.36) | 0.93 (0.62, 1.38) | ||||||
| Unprocessed meat, servings/wk | |||||||||
| 0–<1 (0–<85 g/wk) | 139 | 287,700 | 1.00 | 112 | 142,804 | 1.00 | 27 | 144,896 | 1.00 |
| 1–<3 (85–<255 g/wk) | 267 | 510,430 | 1.16 (0.93, 1.44) | 198 | 227,476 | 1.15 (0.90, 1.47) | 69 | 282,953 | 1.20 (0.75, 1.90) |
| ≥3 (≥255 g/wk) | 158 | 318,047 | 1.24 (0.94, 1.65) | 110 | 116,868 | 1.29 (0.93, 1.79) | 48 | 201,179 | 1.17 (0.67, 2.06) |
| Ptrend3 | 0.2 | 0.1 | 0.7 | ||||||
| Continuous, per 100 g/d | 1.33 (1.03, 1.71) | 1.41 (1.05, 1.88) | 1.15 (0.70, 1.90) | ||||||
1
BWHS, Black Women's Health Study; CRC, colorectal cancer.
2
The model was adjusted for age (continuous), total energy intake (kcal/d), fiber (g/d), discretionary fat (g/d), BMI (<25, 25–29.9, or ≥30), history of type 2 diabetes, alcohol intake (g/d), cigarette smoking (never, current, former; pack-y), aspirin use (nonregular or regular use, defined as ≥3 d/wk), vigorous physical activity (none, <5 h/wk, ≥5 h/wk), and years of education (≤12, 13–15, 16, ≥17 y).
3
Tests of linear trend were calculated by assigning the median of each category as scores.