Table 4.

Key Studies on Congenital Transmission of Chagas Disease in the United States

Study	Key Finding
Perez-Zetune et al 2020 [6]	In the US, congenital Chagas disease screening is cost-saving for all rates of congenital transmission ≥ 0.001% and all levels of maternal prevalence ≥ 0.06%. Targeted screening saves $1314 per birth
Yarrington et al 2019 [28]	0.5% prevalence in screening of 619 Latinaa pregnant women in East Boston
Edwards et al 2015 [29]	0.25% prevalence in screening of 4000 Latinaa mothers in Texas at delivery
CDC 2012 [30]	First US documented case of congenital Chagas disease in Virginia
Di Pentima et al 1999 [31]	0.3% prevalence in screening of 3765 pregnant women in Houston (Latina and non-Latina)

Latina refers to ethnicity, not necessarily birth in a Chagas disease-endemic country in Latin America.