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. 2021 Dec 1;50(8):4201–4215. doi: 10.1093/nar/gkab1150

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Comparison of modification profiles in tRNA and RF upon in cellulo degradation post-mortem. (A) Heatmaps represent modification content of tRNA-fractions from mouse brain and liver tissue isolated at different time points post mortem and in comparison with unfrozen samples. Each row was normalized by its mean. n = 4 biological replicates. (B) At different time points post mortem and in comparison with unfrozen samples. Modifications with signals below 5x S/N across all samples are represented by grey bars.