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. 2021 Dec 1;50(8):4201–4215. doi: 10.1093/nar/gkab1150

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Comparison of different mouse brain tissues (cohort 1). (A) Heatmap displaying tRNA and RF modification content of different brain areas. From n = 16 mice, the material of two mice were pooled, resulting in 8 biological replicates. (B) Sketch of localization of cortex, hippocampus and cerebellum in a mouse brain sagittal cut. (C) Principal component analysis of brain area samples from (B). rRNA modifications in dark grey were omitted from the analysis. Modifications with signals below 5× S/N across all samples are represented by light grey bars.