TABLE 2.
Demographic data in the 3 cohorts of ALS subjects at the baseline visit1
| Comparison, P value2 | |||||
|---|---|---|---|---|---|
| Cohort #1 (n = 29) | Cohort #2 (n = 104) | Cohort #3 (n = 314) | Cohort #1 vs. Cohort #2 | Cohort #1 vs. Cohort #3 | |
| Males | 72 | 63 | 65 | 0.32 | 0.41 |
| Site of onset | 0.12 | 0.13 | |||
| Limb | 83 | 70 | 70 | ||
| Bulbar | 13 | 29 | 28 | ||
| Axial | 4 | 1 | 2 | ||
| Limb + bulbar | 0 | 0 | 0.4 | ||
| Age at 1st visit, y | 57.4 ± 14.0 | 59.1 ± 10.9 | 60.1 ± 12.6 | 0.50 | 0.28 |
| Median disease duration at 1st visit, mo | 24 | 15 | 17.4 | 0.03 | 0.03 |
| Height, cm | 169 ± 11 | 172 ± 10 | 171 ± 10 | 0.22 | 0.43 |
| Weight, kg | 70.6 ± 12.5 | 82.2 ± 18.2 | 78.2 ± 17.4 | <0.001 | 0.01 |
| BMI, kg/m2 | 24.6 ± 3.7 | 27.6 ± 5.0 | 26.6 ± 4.8 | <0.001 | 0.01 |
| ALSFRS-R score | 37.3 ± 6.0 | 36.9 ± 5.4 | 37.1 ± 5.8 | 0.72 | 0.83 |
| Predicted FVC3 | 86.3 ± 23.8 | 80.6 ± 17.6 | 81.1 ± 22.3 | 0.23 | 0.23 |
1
All values are percentages or means ± SDs, unless indicated otherwise. ALS, amyotrophic lateral sclerosis; ALSFRS-R, ALS functional rating scale-revised (normal = 48); FVC, forced vital capacity.
2
P values are from t tests.
3
Percentage corrected for age, sex, and height.