Table 2.

Odds Ratios (ORs) of Prevalent Frailty by Average Annual NSAID Use Among 12 101 Physicians’ Health Study Participants

Model	OR of Frail vs Nonfrail*	95% CI	p-Trend
Frailty determined using frailty index score ≥0.21
0 days/year	Ref	—	<.001
≤12 days/year	0.91	0.80–1.03
13–60 days/year	1.02	0.89–1.17
>60 days/year	1.26	1.07–1.49
Frailty determined using mSOF score ≥2 (n = 12 028)
0 days/year	Ref	—	<.001
≤12 days/year	1.15	0.96–1.37
13–60 days/year	1.53	1.27–1.85
>60 days/year	1.95	1.56–2.43

Notes: CI = confidence interval; mSOF score = modified Study of Osteoporotic Fracture score; NSAID = nonsteroidal anti-inflammatory drug.

*All models were run after the propensity score weighting was applied.