Table 3.

Odds Ratios (ORs) of Prevalent Frailty by NSAID Category, Stratified by Age, Major Comorbidities, and Aspirin Use

Variable	Model*	OR of Frailty vs Nonfrail	95% CI	p-Interaction
Age
<75 N = 8 942	≤12 days/year	1.18	0.98–1.43	.51
	13–60 days/year	1.65	1.35–2.02
	>60 days/year	3.12	2.49–3.91
≥75 N = 3 159	≤12 days/year	1.21	1.00–1.47
	13–60 days/year	1.69	1.36–2.10
	>60 days/year	2.57	1.99–3.33
Coronary heart disease
No N = 10 112	≤12 days/year	1.00	0.86–1.17	.08
	13–60 days/year	1.42	1.21–1.68
	>60 days/year	2.66	2.20–3.21
Yes N = 1 989	≤12 days/year	1.02	0.78–1.34
	13–60 days/year	1.24	0.93–1.67
	>60 days/year	1.68	1.22–2.32
Arthritis
No N = 8 529	≤12 days/year	0.97	0.83–1.14	.20
	13–60 days/year	1.12	0.92–1.36
	>60 days/year	1.77	1.36–2.30
Yes N = 3 572	≤12 days/year	0.68	0.53–0.87
	13–60 days/year	0.78	0.60–0.995
	>60 days/year	1.08	0.83–1.40
Gastrointestinal bleeding
No N = 10 602	≤12 days/year	1.01	0.88–1.16	.80
	13–60 days/year	1.38	1.19–1.62
	>60 days/year	2.49	2.09–2.98
Yes N = 1 499	≤12 days/year	0.93	0.67–1.30
	13–60 days/year	1.48	1.03–2.12
	>60 days/year	2.53	1.68–3.82
Renal disease
No N = 11 260	≤12 days/year	1.00	0.87–1.14	.08
	13–60 days/year	1.40	1.20–1.62
	>60 days/year	2.61	2.20–3.10
Yes N = 841	≤12 days/year	1.09	0.73–1.64
	13–60 days/year	1.41	0.90–2.19
	>60 days/year	1.69	1.01–2.82
Average aspirin use
<90 days/year N = 2358	≤12 days/year	0.84	0.65–1.10	.24
	13–60 days/year	1.20	0.89–1.62
	>60 days/year	1.94	1.38–2.73
≥90 days/year N = 9743	≤12 days/year	1.07	0.92–1.24
	13–60 days/year	1.49	1.27–1.75
	>60 days/year	2.75	2.29–3.31
Pain**
No N = 4136	≤12 days/year	0.97	0.76–1.17	.58
	13–60 days/year	1.05	0.80–1.38
	>60 days/year	1.85	1.27–2.70
Yes N = 7965	≤12 days/year	0.91	0.77–1.07
	13–60 days/year	1.26	1.06–1.50
	>60 days/year	2.15	1.77–2.61

Notes: CI = confidence interval; NSAID = nonsteroidal anti-inflammatory drug.

*Reference = no NSAID use.

**Pain: migraine, headache, or arthritis.