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. 2021 Oct 4;50(8):4315–4328. doi: 10.1093/nar/gkab859

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Analysis of plasmid CRISPR spacer contents reveals a plasmid targeting bias. The proportion of plasmid (A) and plasmid-host (B) chromosomal spacers matching plasmids (green) and viruses (grey). (C) Distribution of spacer-protospacer matches derived from plasmid (left) and plasmid-host chromosome (right) spacer contents, presented according to CRISPR-Cas subtype/variant and predicted spacer target: plasmids (green) and viruses (grey). Only the top 8 subtypes for both plasmids and chromosomes are represented, with the remaining grouped in ‘Other’. (D) Distribution of spacer-protospacer matches derived from plasmid (left) and host chromosome (right) spacer contents, broken down by host taxa and predicted protospacer origin: plasmids (green) and viruses (grey). Only the top 6 classes for both plasmids and chromosomes are represented, with the remaining classes grouped in ‘Other’.