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. 2021 Nov 15;31(9):1471–1486. doi: 10.1093/hmg/ddab330

Figure 1.

Figure 1

FBXO7 copy number alterations are frequent and associated with worse overall survival in cancer. (A) Bar graph presenting FBXO7 copy number alterations from TCGA PanCancer Atlas data for 12 common solid cancer types (total cases) (27–29). Note ~30% of CRC cases exhibit shallow deletions (i.e. heterozygous loss) of FBXO7. (B) Violin plots of TCGA PanCancer Atlas data for CRC identify positive linear relationships between FBXO7 copy number alterations and mRNA expression (27–29). Dotted and dashed lines within the violin plots identify 25th/75th and 50th percentiles, respectively. The various copy number categories (deep deletion; shallow deletion; diploid; gain; amplification) are indicated along the x-axis with the total number of cases indicated in brackets. Student’s t-test identifies a statistically significant difference in mean FBXO7 expression levels between samples harboring shallow deletions relative to normal diploid controls (****P-value <0.0001). (C) Kaplan–Meier curves reveal significantly worse progression-free (left), disease-specific (middle) and overall (right) survival for CRC patients harboring shallow FBXO7 deletions relative to those with normal (diploid) copy numbers (27–29). Case numbers are indicated within brackets.