Figure 7.

The performance of scMAGIC by using the atlas expression matrix as the reference. Panel (A) shows the bar plot of the accuracy, the balanced accuracy, the labeled accuracy and the labeled balanced accuracy of scMAGIC, scMCA and scHCL by using the atlas expression matrix as the reference to annotate four query datasets. For details about the query datasets, refer to Supplementary Table S1. Each benchmark test is represented by the tissue of a query dataset. Panels (B–E) show the heatmaps of the confusion matrices of scMAGIC by using MCA (B and C) or HCL (D and E) as the reference to annotate mouse neocortex (B), mouse duodenum (C), human pancreas (D) and human PBMC (E), respectively. Each confusion matrix is arranged in the same way as the confusion matrices in Figure 3B–E. Note that peripheral vascular macrophage (PVM) and microglia are combined into one cell type by the authors, and oligodendrocyte and oligodendrocyte precursor cell (OPC) are also combined into one cell type in (B); VLMC, vascular and leptomeningeal cell; ASC, activated stellate cell; QSC, quiescent stellate cell.