TABLE 2.

Associations of 18-mo MRI-derived changes in HOC and LVV with changes in anthropometric measurements and blood biomarkers¹

	18-mo relative change in HOC				18-mo relative change in LVV
	Entire		Age ≥ 50 y		Entire		Age ≥ 50 y
	r	P value	r	P value	r	P value	r	P value
∆Weight	0.008	0.904	−0.211	0.027	0.233	<0.001	0.411	<0.001
∆BMI	0.011	0.875	−0.21	0.028	0.226	0.001	0.392	<0.001
∆Waist circumference	0.02	0.769	−0.11	0.254	0.213	0.001	0.246	0.009
∆Systolic BP	−0.145	0.034	−0.175	0.069	0.139	0.041	0.134	0.195
∆Diastolic BP	−0.142	0.038	−0.171	0.075	0.232	0.001	0.182	0.056
∆HOMA-IR	−0.111	0.108	−0.301	0.002	0.147	0.031	0.231	0.015
∆Triglycerides	−0.011	0.869	−0.206	0.032	0.086	0.202	0.084	0.381
∆Cholesterol	−0.017	0.799	−0.052	0.590	−0.035	0.606	−0.088	0.360
∆HDL-C	−0.037	0.592	0.015	0.878	−0.087	0.198	−0.116	0.225
∆LDL-C	−0.01	0.879	0.024	0.808	−0.03	0.658	−0.104	0.277

¹Univariate correlation matrix of 18-mo relative change in MRI HOC and LVV and 18-mo changes in selected parameters of the entire cohort and in participants who were ≥50 y of age at baseline. Brain MRI-derived data were quantified and segmented in a fully automated manner using NeuroQuant. The analysis was performed using Pearson or Spearman correlation, depending on the variable distribution. BP, blood pressure; HDL-C, HDL cholesterol; HOC, hippocampal occupancy score; LDL-C, LDL cholesterol; LVV, lateral ventricle volume.