TABLE 3.

HRs and 95% CIs for the primary endpoints according to subgroup and randomization arm¹

Endpoint	Number of participants	Placebo	1600 IU/day	3200 IU/day	P value for trend	P value for interaction
Major cardiovascular event2
Men (events, n)	1426	34	26	30		0.02
		1	0.70 (0.42–1.16)	0.81 (0.50–1.33)	0.43
Women (events, n)	1069	7	16	6
		1	2.44 (1.00–5.93)	0.91 (0.30–2.69)	0.92
Age < median 67.4 year (events, n)	1247	25	16	20		0.27
		1	0.64 (0.34–1.19)	0.80 (0.45–1.45)	0.47
Age ≥ median 67.4 year (events, n)	1248	16	26	16
		1	1.49 (0.80–2.78)	0.92 (0.46–1.84)	0.87
BMI < median 26.4 kg/m2 (events, n)	1250	9	20	23		0.003
		1	2.07 (0.94–4.55)	2.28 (1.05–4.92)	0.04
BMI ≥ median 26.4 kg/m2 (events, n)	1245	32	22	13
		1	0.66 (0.38–1.14)	0.41 (0.22–0.79)	0.01
BMI <25 kg/m2 (events, n)	850	6	13	12		0.09
		1	1.93 (0.73–5.08)	1.60 (0.60–4.25)	0.39
BMI 25–30 kg/m2 (events, n)	1136	22	24	22
		1	1.02 (0.57–1.82)	1.01 (0.56–1.83)	0.81
BMI ≥30 kg/m2 (events, n)	509	13	5	2
		1	0.43 (0.15–1.21)	0.19 (0.04–0.82)	0.004
Any cancer
Men (events, n)	1426	37	38	33		0.38
		1	0.92 (0.59–1.45)	0.82 (0.51–1.31)	0.42
Women (events, n)	1069	25	33	29
		1	1.44 (0.86–2.42)	1.24 (0.73–2.12)	0.42
Age < median 67.4 year (events, n)	1247	28	29	24		0.98
		1	1.02 (0.61–1.71)	0.88 (0.51–1.51)	0.63
Age ≥ median 67.4 year (events, n)	1248	34	42	38
		1	1.20 (0.76–1.89)	1.07 (0.68–1.71)	0.80
BMI < median 26.4 kg/m2 (events, n)	1250	38	35	35		0.33
		1	0.89 (0.57–1.42)	0.84 (0.53–1.33)	0.47
BMI ≥ median 26.4 kg/m2 (events, n)	1245	24	36	27
		1	1.49 (0.89–2.49)	1.19 (0.69–2.07)	0.53
BMI <25 kg/m2 (events, n)	850	24	19	26		0.39
		1	0.72 (0.39–1.31)	0.88 (0.51–1.53)	0.71
BMI 25–30 kg/m2 (events, n)	1136	28	37	28
		1	1.36 (0.83–2.23)	1.14 (0.67–1.93)	0.76
BMI ≥30 kg/m2 (events, n)	509	10	15	8
		1	1.61 (0.72–3.59)	0.91 (0.36–2.32)	0.84

¹Adjusted for age and sex in the Cox proportional hazards regression model.

²Composite endpoint of myocardial infarction, stroke, and cardiovascular disease mortality.