Table 1.
Study characteristics
| Trial | First author (year) | CABG patients (n) | Country | Study period | Intervention/comparison groups | Outcome assessments | Follow-up time points (months) |
|---|---|---|---|---|---|---|---|
| ART | Little (2021)51 | 2943 | Australia, Austria, Brazil, India, Italy, Poland, UK | 2004–07 | CABG: SITA vs. BITA | EQ-5D | B, 1, 5 |
| BBS | Østergaard (2016)50 | 120 | Denmark | 2002–04 | CABG: off-pump vs. on-pump | SF-36 | B, 3, 12, 96 |
| CARRPO | Damgaard (2011) | 331 | Denmark | 2002–05 | CABG: total arterial vs. conventional | SF-36 | B, 3, 11 |
| CORONARY | Lamy (2016) | 2850 | NR, worldwide | 2006–11 | CABG: off-pump vs. on-pump | EQ-5D, EQ-5D visual analogue | B, 1, 12, 60 |
| CRISP | Rogers (2014) | 98 | UK, India, Brazil, Canada, Germany, Italy | 2009–11 | CABG: off-pump vs. on-pump | EQ-5D | B, 4–8 weeks |
| CSP474 | Bakaeen (2012) | 725 | USA | 2003–09 | CABG: radial vs. SVG, residents vs. attendees | SAQ | B, 3, 12 |
| DOORS | Houlind (2012) | 900 | Denmark | 2005–08 | CABG: off-pump vs. on-pump | SF-36, EQ-5D | B, 6 |
| EXCEL | Baron (2017) | 896 | NR, worldwide | 2010–14 | CABG vs. PCI | SAQ, SF-12, PHQ-8 | B, 1, 12, 36 |
| FREEDOM | Abdallah (2013) | 935 | NR, worldwide | 2005–10 | CABG vs. PCI | SAQ | B, 1, 6, 12 |
| Magnuson (2013) | 911 | EQ-5D | |||||
| MOTIV-CABG | Perrotti (2016) | 217 | France | 2006–12 | CABG: MDD vs. no MDD | SF-36 | B, 1, 3, 6, 12 |
| ROOBY | Bishawi (2013) | 2127 | USA | 2002–07 | CABG: off-pump vs. on-pump | SAQ, VR-36 | B, 12 |
| STICH | Mark (2014) | 610 | NR, worldwide | 2002–07 | Medical therapy vs. medical therapy + CABG | KCCQ, SAQ, SF-12, SF-36 | B, 4, 12, 24, 36 |
| SYNTAX | Cohen (2011)Cohen (2014) Abdallah (2017) | 897 870 848 | Austria, Belgium, Denmark, Finland, France, Germany, Hungary, Italy, the Netherlands, Poland, Spain, Sweden, UK, USA | 2005–07 | CABG vs. PCI | SAQ, SF-36 EQ-5D SAQ, SF-36 | B, 1, 6, 12 B, 1, 6, 12, 36, 60 |
| n/a | Anastasiadis (2016) | 60 | Greece | 2014 | CABG: MiECC vs. cCPB | SF-36 | B, 1, 3 |
| n/a | Fakhrzad (2016) | 200 | Iran | 2014 | CABG vs. PCI | SF-36, SAQ | 1, 6 |
B, baseline; cCPB, conventional cardiopulmonary bypass; EQ-5D, EuroQol 5 Dimensions Questionnaire; HUI, Health utilities index; MDD, major depressive disorder; MiECC, minimally invasive extracorporeal circulation; NR, not reported; SVG, saphenous vein graft; PCI, percutaneous coronary intervention; PHQ-8, Patient Health Questionnaire-8; SAQ, Seattle Angina Questionnaire; SF-12, 12-item Short-Form Health Survey; SF-36, 36-item Short-Form Health Survey; SVG, saphenous vein graft; VR-36, Veteran versions of the Short Form.