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. 2021 Sep 11;61(5):1877–1884. doi: 10.1093/rheumatology/keab622

Table 3.

Univariable and multivariable models for incident PsA

HR (95% CI)
Univariable Multivariable (model 1) Multivariable (model 2) Sensitivity analysis (followed yearly, n = 5975)
Age 0.99 (0.98, 1.00) 0.99 (0.97, 1.01) 0.99 (0.98, 1.00) 0.98 (0.97, 1)
Sex 0.80 (0.60, 1.06) 0.75 (0.53, 1.07) 0.72 (0.52, 1.00) 0.63 (0.46, 0.87)
BMI 1.05 (1.02, 1.07)
Obese 1.76 (1.29, 2.40) 1.49 (1.05, 2.13) 1.64 (1.19, 2.26) 1.49 (1.08, 2.06)
Smoker
 Never Ref
 Current 0.93 (0.65, 1.33)
 Past 1.29 (0.92, 1.81)
BSA
 Continuous BSA (per 1% unit) 1.02 (1.01, 1.03)
 Continuous BSA (per 5% unit) 1.09 (1.04, 1.16) 1.08 (1.01, 1.14)
 Mild (<3%) Ref Ref
 Moderate (3–10%) 1.55 (1.12, 2.14) 1.44 (1.02, 2.03) 1.38 (0.98, 1.95)
 Severe (>10%) 2.41 (1.61, 3.6) 2.01 (1.19, 3.13) 1.82 (1.17, 2.84)
Anxiety 1.00 (0.70, 1.42)
Depression 1.45 (1.08, 1.95) 1.73 (1.21, 2.47) 1.68 (1.21, 2.33) 1.54 (1.12, 2.13)
Diarrhoeal illness 1.38 (1.00, 1.92)
Duration 5+ years (vs <5) 1.37 (1.01, 1.87)
Hyperlipidaemia 1.03 (0.65, 1.63)
Hypertension 1.14 (0.78, 1.65)
Diabetes 0.75 (0.41, 1.38)
Liver disease 0.92 (0.30, 2.89)
COPD 0.89 (0.28, 2.78)
Fracture 1.02 (0.74, 1.41)
Anxiety 1.00 (0.70, 1.42)
Substance abuse 0.85 (0.27, 2.65)
Thyroid disease 1.15 (0.63, 2.12)
Pharyngitis 1.19 (0.87, 1.63)
Crohn’s disease 1.05 (0.15, 7.52)

Multivariable models include those covariates with a HR in the respective column. Model 1 includes BSA as a continuous variable (per increase of 5%), obesity (BMI ≥30 vs BMI <30), and depression (binary) and adjusts for age and sex. Model 2 includes BSA by category (mild, moderate and severe), obesity and depression and adjusts for age and sex. Psoriasis duration was not statistically significant in the multivariable model. BSA: body surface area; COPD: chronic obstructive pulmonary disease; HR: hazard ratio; Ref: reference group.