Table 2.
Predictors of pneumocystis pneumonia according to treatment with glucocorticoids
| Predictors | Total (n = 929) | GC (–) (n = 496) | GC (+) (n = 433) |
|---|---|---|---|
| RR (95% CI) | RR (95% CI) | RR (95% CI) | |
| Univariable analysis | |||
| Age | 1.085* (1.035, 1.146) | 1.103* (1.025, 1.212) | 1.073* (1.010, 1.115) |
| Concomitant GC use | 1.247* (0.480, 3.241) | – | – |
| Coexisting lung disease | 3.979* (1.517, 10.43) | 5.582* (1.315, 23.68) | 3.043* (0.805, 11.50) |
| b/ts-DMARDs, mechanism of action | P value = 0.67 | P value = 0.34 | P value = 0.91 |
| Number of past b/ts-DMARDs use | 1.177* (0.470, 2.157) | 1.699* (0.635, 3.112) | 0.521* (0.032, 1.880) |
| BMI (kg/m2) | 1.033* (0.912, 1.117) | 1.194* (1.003, 1.392) | 0.902* (0.728, 1.074) |
| eGFR (ml/min/1.73 m2) | 0.989* (0.974, 1.006) | 0.971* (0.947, 0.996) | 1.003* (0.982, 1.026) |
| Neutrophil count (/μl) | 1.000* (1.000, 1.000) | 1.000* (1.000, 1.001) | 1.000* (1.000, 1.000) |
| Lymphocyte count (/μl) | 0.999* (0.998, 1.000) | 0.999* (0.997, 1.000) | 1.000* (0.998, 1.001) |
| Serum albumin (g/dl) | 0.279* (0.121, 0.691) | 0.322* (0.095, 1.325) | 0.250* (0.078, 0.869) |
| Serum IgG (mg/dl) | 0.998* (0.997, 0.999) | 0.997* (0.995, 0.999) | 0.999* (0.997, 1.000) |
| Multivariable analysis | Model 1 | Model 2 | Model 3 |
| Age | 1.060* (1.008, 1.121) | 1.092* (1.005, 1.206) | 1.073* (1.010, 1.150) |
| Concomitant GC use | |||
| Coexisting lung disease | 5.128* (1.028, 25.57) | ||
| BMI (kg/m2) | 1.251* (1.064, 1.459) | ||
| eGFR (ml/min/1.73 m2) | |||
| Neutrophil count (/μl) | |||
| Lymphocyte count (/μl) | 0.998* (0.996, 0.999) | ||
| Serum albumin (g/dl) | 0.270* (0.108, 0.734) | ||
| Serum IgG (mg/dl) | 0.998* (0.997, 0.999) | 0.997* (0.995, 0.999) | |
| Bootstrapping resampling | Model 1 | Model 2 | Model 3 |
| Age | 1.062* (1.021, 1.117) | 1.114* (1.002, 1.190) | 1.077* (1.022, 1.133) |
| Concomitant GC use | |||
| Coexisting lung disease | 9.360* (1.080, 49.40) | ||
| BMI (kg/m2) | 1.268* (1.098, 1.451) | ||
| eGFR (ml/min/1.73 m2) | |||
| Neutrophil count (/μl) | |||
| Lymphocyte count (/μl) | 0.998* (0.997, 0.999) | ||
| Serum albumin (g/dl) | 0.296* (0.129, 0.664) | ||
| Serum IgG (mg/dl) | 0.998* (0.997, 0.999) | 0.997* (0.995, 0.999) |
Values are risk ratio (RR) and 95% confidential interval. *P <0.05. Cox proportional hazard regression analysis using data for all participants and participants with/without concomitant glucocorticoid (GC) treatment. Variables were measured at baseline. GFR, glomerular filtration rate.