Fig. 9.

Cartoon representation of Nup60 inhibition. a) In the absence of Nup2, Nup60’s pro-sporulation function is inactive due to inhibition via its own C-terminus. The mechanism by which this repression occurs is unknown. b) Binding of the Nup2 MAR to Nup60 counteracts inhibition by the C-terminus, and Nup60 becomes active. c) When the C-terminus is deleted, Nup60 is active, even in the absence of Nup2. The cartoon is meant to depict functional interactions between the MAR and regions of Nup60 and does not necessarily represent actual physical interactions.