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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Semin Cell Dev Biol. 2021 Jun 10;124:85–98. doi: 10.1016/j.semcdb.2021.05.030

Figure 1. MicroRNAs shape all aspects of periodontal inflammation.

Figure 1.

This sketch illustrates the multiple sites of action and diverse functions of miRs in the regulation of periodontal inflammation, some of which are reviewed in this article, including (i) miRs involved in the gingival response against pathogens, (ii) miRs involved in periodontal homeostasis, (iii) viral miRs. In turn miR function is altered by sponge-like long non-coding RNAs or through miR polymorphism. As part of the inflammatory response, miRs control the expression of sets of related genes and have an enormous impact on the periodontal host response against periodontal pathogens and even affect gene expression within some of the pathogens, such as herpesvirus populations residing within the periodontal lesion.