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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Semin Cell Dev Biol. 2021 Jun 10;124:85–98. doi: 10.1016/j.semcdb.2021.05.030

Table 1.

miRNA regulation of Inflammation in gingival tissues

miRNAs Expression Targets Function References
miR-205 Downregulated IL-6st Increase IL-1, IL-6 and TNF-a expression, Activate JAK/STAT3 signaling Li et al. 2020
miR-335 Downregulated TPX2 Increase IL-1, IL-6 and TNF-a expression, Activate JAK/STAT3 signaling Lian et al. 2019
Gu et al. 2020
miR-21 Upregulated PDCD4 Increase IL-1, IL-6 and TNF-a expression Zhou et al. 2018
miR-144 Upregulated COX2, IL-7F Inhibit autophagy Li et al. 2019, Yao et al. 2018
miR-146a Upregulated IRAK1 Increase IL-1, IL-6 and TNF-a expression Sanada et al. 2020
Jiang et al. 2018
miR-214 Upregulated ATF-4 Cell life-death decision, and apoptosis-necroptosis switch Ou et al. 2019
miR-200b Upregulated VEGF, EZB1, GATA2 Inhibit angiogenesis Magental et al. 2011, Chan et al. 2012
miR-203 Upregulated SOCS3/6 Increase IL-1, IL-6 and TNF-a expression, Activate SOCS/STAT3 signaling Moffatt and Lamont, 2011