Table 2.

miRNA regulation of PDL cell function

miRNAs	Treatments	Targets	Functions	References
miR-132	LPS	AKT	AKT signaling PDL Proliferation/apoptosis	Han et al. 2019 Dong et al. 2020
miR-143	LPS	AKT	AKT signaling PDL Proliferation/apoptosis	Duan et al. 2020
miR-302b	LPS	AKT	AKT signaling PDL Proliferation/apoptosis	Duan et al. 2020 Guo et al. 2017
miR-24	H2O2	XIAP	AKT signaling PDL apoptosis	Liu et al. 2016
miR-222	High glucose	Caspase 3	PDL apoptosis	Monteiro et al. 2020
miR-223	High glucose	Caspase 3	PDL apoptosis	Monteiro et al. 2020
miR-646	Low O2	IGF-1	PDL apoptosis	Yang et al. 2018
miR-21	TNF-a	SPRY-1	PDL differentiation	Yang et al. 2017
miR-138	LPS, IL-6	OCN	PDL differentiation	Zhou et al. 2016
miR-148	LPS	NRP1	PDL differentiation	Bao et al. 2019
miR-181b	TNF-a	IL-6	Cementoblast apoptosis	Wang et al. 2019
miR-155	TNF-a	KCTD1	Cementoblast differentiation	Wang et al. 2017
miR-325	Osteogenic induction	RUNX2	Cementoblast differentiation	Wang et al. 2020