TABLE 4.
Summary of amino acid substitutions in Erg11p and gene overexpression in fluconazole-resistant C. albicans isolates compared to matched susceptible isolates
| Patient | Isolate | Fluconazole MIC (μg/ml) | Amino acid substitutions in Erg11p | Gene overexpression |
|---|---|---|---|---|
| 7 | 412 | 0.5 | K128T | |
| 2307 | >64 | K128T | ERG11, CDR, CDR1, and CDR2 | |
| 9 | 1002 | 0.25 | ||
| 2823 | >64 | ERG11, MDR1, and CDR2 ERG11 | ||
| 3795 | >64 | |||
| 14 | 580 | 4 | ||
| 2440 | 64 | V437I | V437I, ERG11, and MDR1 | |
| 2500 | 64 | V437I | V437I, ERG11, and MDR1 | |
| 15 | 945 | 8 | D116E and G450E | |
| 1619 | 64 | D116E and G450E | ERG11 and CDR2 | |
| 16 | 3107 | 4 | Y132F | |
| 3119 | >64 | Y132F | MDR1 | |
| 3120 | >64 | Y132F | MDR1 | |
| 3184 | 64 | Y132F | CDR | |
| 3281 | 64 | Y132F | CDR | |
| 28 | 5044 | 4 | V437I and D446N | |
| 5052 | 64 | V437I and D446N | MDR1, CDR, CDR1, and CDR2 | |
| 30 | 5106 | 8 | V437I | |
| 5108 | 64 | V437I and G464S | ERG11, MDRI, CDR, and CDR1 | |
| 42 | 1691 | 0.25 | K128T | |
| 3731 | >64 | F126L and K143R | MDR1 | |
| 3733 | 64 | F126L and K143R | MDR1 | |
| 43 | 1649 | 0.5 | ||
| 3034 | >64 | MDR1, CDR, CDR1, and CDR2 | ||
| 51 | 2274 | 16 | S405F | |
| 2257 | 64 | S405F | ||
| 2339 | 64 | S405F | CDR, CDR1, and CDR2 | |
| 59 | 3917 | 4 | F449S | |
| 4617 | 64 | F449S and T229A | MDR1, CDR, and CDR1 | |
| 4639 | >64 | F449S and T229A | ||
| 64 | 4018 | 4 | ||
| 4380 | 64 | V437I | CDR, CDR1, and CDR2 |