FIG. 2.

Mean plasma (A) and lung (B) ABT-773 concentrations in guinea pigs with L. pneumophila pneumonia. Animals were given a single 10-mg/kg dose administered by the intraperitoneal route at time zero. For each time point except the 6-h time point, samples were obtained from three animals; samples were obtained from two animals for the 6-h time point. One plasma sample taken at 3, 4, and 6 h each contained no detectable drug. The vertical bars represent the ranges for each time point. The dotted line shows the one-component exponential decay regression curve for each data set (r ² = 0.66 for plasma and 0.76 for the lungs). The horizontal dashed line in panel A shows the lower limit of detection.