TABLE 3.

Uffect of amidation on antimicrobial activity^a

Organism	Strain	P	Mean MEC (mM) ± SEM
			LL-37	LL-37pam	RL-37
Group B strep	A12973	0.019	8.37 ± 2.09 (8)	2.27 ± 0.41 (7)	>79.0 (3)
L. acidophilus	A4356	NS	18.6 ± 6.1 (4)	9.0 ± 1.7 (4)	NT
K. pneumoniae	2270	0.02	1.81 ± 0.02 (9)	0.76 ± 0.14 (7)	0.73 ± 0.06 (3)
P. aeruginosa	MR3007	0.012	1.28 ± 0.18 (10)	0.73 ± 0.05 (9)	1.26 ± 0.08 (3)
E. coli	ML-35p	NS	0.66 ± 0.07 (9)	0.61 ± 0.04 (6)	0.57 ± 0.01 (3)
E. coli	A33780	NS	5.57 ± 0.15 (3)	6.47 ± 0.39 (3)	5.74 ± 0.39 (3)

^aRadial diffusion assays were performed with underlay gels that contained 100 mM NaCl; 10 mM sodium phosphate buffer, pH 7.4; and Trypticase soy broth powder, 30 mg/ml. P values (for LL-37 versus LL-37 PAM) were calculated by the t test. Abbreviations: NT, not tested; NS, not significant.