Statistically significant differentially regulated serum metabolites identified through the LC-MS based targeted approach.

Sr. no.	Metabolite	VIP score	p-Value	FDR adjusted p-value	Fold change	AUC	Control CV%	MM CV%
1	NAD	1.69	1.28 × 10−23	7.97 × 10−22	17.56	0.97	16.49	13.84
2	Adenosine	1.69	1.99 × 10−23	7.97 × 10−22	13.78	0.97	23.65	18.12
3	CYTIDINE	1.63	1.78 × 10−16	3.56 × 10−15	5.56	0.97	23.68	23.49
4	Adenine	1.60	9.36 × 10−17	2.50 × 10−15	3.62	0.98	27.44	17.32
5	Oxaloacetic acid	1.55	9.02 × 10−16	1.44 × 10−14	0.01	0.99	18.23	17.46
6	Guanosine	1.51	5.17 × 10−14	6.89 × 10−13	3.03	0.97	21.45	25.68
7	l-Methionine	1.38	2.41 × 10−9	2.75 × 10−8	0.60	0.94	24.58	27.84
8	Mono-ethylmalonate	1.38	3.06 × 10−9	3.06 × 10−8	0.63	0.92	27.96	21.52
9	l-Leucine	1.34	4.65 × 10−8	4.13 × 10−7	0.67	0.91	14.94	16.75
10	l-Homoserine	1.31	2.56 × 10−7	2.05 × 10−6	0.64	0.90	22.34	25.73
11	l-Threonine	1.30	4.42 × 10−7	2.95 × 10−6	0.64	0.89	25.62	21.98
12	Thymine	1.28	3.68 × 10−6	1.92 × 10−5	0.62	0.87	18.82	16.72
13	Methyl malonate	1.18	3.48 × 10−7	2.53 × 10−6	1.63	0.90	12.57	15.64
14	l-Citrulline	1.17	3.02 × 10−6	1.86 × 10−5	0.52	0.86	18.93	21.88
15	Uracil	1.17	2.49 × 10−5	9.04 × 10−5	0.65	0.81	28.72	24.42
16	l-Cysteine	1.17	1.79 × 10−5	6.83 × 10−5	0.71	0.84	22.26	26.84
17	l-Arginine	1.15	1.79 × 10−5	6.83 × 10−5	0.65	0.82	15.82	19.68
18	Xanthosine dihydrate	1.09	0.000619	0.001415	0.62	0.76	25.68	18.94
19	Riboflavin	1.09	4.14 × 10−6	1.95 × 10−5	2.90	0.87	19.84	23.46
20	UTP	1.08	4.98 × 10−5	0.000159	0.49	0.92	22.56	26.78
21	Succinic acid	1.07	4.09 × 10−5	0.000136	1.50	0.84	14.98	21.36
22	l-Glutamine	1.06	6.66 × 10−5	0.000197	0.67	0.81	18.96	19.14
23	Xylitol	1.04	0.000213	0.000567	1.73	0.86	22.46	21.58
24	Adonitol	1.04	0.000124	0.000355	1.81	0.87	18.92	27.65
25	Cytosine	1.01	6.42 × 10−5	0.000197	2.96	0.85	19.74	23.74
26	Thyroxine	1.00	0.000147	0.000406	0.60	0.79	29.76	19.52