Statistically significant differentially regulated serum metabolites identified through the GC-MS based untargeted approach.
| Sr. no. | Metabolite | VIP score | p-Value | FDR adjusted p-value | Fold change | AUC | Control CV% | MM CV% |
|---|---|---|---|---|---|---|---|---|
| 1 | d-Ribo-hexitol | 2.30 | 4.20 × 10−20 | 6.43 × 10−18 | 7.08 | 1.00 | 19.36 | 23.58 |
| 2 | Beta-d-glucopyranosiduronic acid | 2.25 | 1.81 × 10−18 | 1.39 × 10−16 | 5.81 | 1.00 | 28.92 | 23.74 |
| 3 | Hexadecanoic acid | 1.93 | 8.82 × 10−8 | 4.50 × 10−6 | 1.80 | 0.95 | 18.62 | 14.85 |
| 4 | 1,5-Anhydro-d-sorbitol | 1.84 | 3.49 × 10−7 | 1.07 × 10−5 | 0.25 | 0.89 | 26.35 | 28.61 |
| 5 | Pseudo uridine | 1.83 | 2.35 × 10−7 | 8.97 × 10−6 | 6.11 | 0.95 | 12.32 | 16.78 |
| 6 | d-Talofuranose | 1.77 | 1.51 × 10−6 | 3.84 × 10−5 | 0.37 | 0.91 | 29.84 | 26.74 |
| 7 | Glucofuranoside | 1.66 | 1.54 × 10−5 | 3.36 × 10−4 | 2.73 | 0.91 | 23.48 | 25.68 |
| 8 | N-Acetyl glucosamine | 1.52 | 2.39 × 10−4 | 3.03 × 10−3 | 0.56 | 0.82 | 19.46 | 23.42 |
| 9 | Purine | 1.51 | 1.15 × 10−4 | 1.88 × 10−3 | 0.45 | 0.84 | 26.59 | 28.32 |
| 10 | Beta-d-galactopyranoside | 1.51 | 1.23 × 10−4 | 1.88 × 10−3 | 0.42 | 0.85 | 21.65 | 25.38 |
| 11 | Pyrimidine | 1.50 | 6.16 × 10−5 | 1.18 × 10−3 | 0.40 | 0.83 | 20.28 | 22.07 |
| 12 | 2-Piperidinecarboxylic acid | 1.50 | 1.60 × 10−4 | 2.22 × 10−3 | 0.44 | 0.81 | 14.63 | 16.09 |
| 13 | d-Lactose | 1.42 | 3.18 × 10−3 | 2.01 × 10−2 | 1.64 | 0.75 | 12.59 | 16.83 |
| 14 | d-Xylofuranose | 1.42 | 4.41 × 10−4 | 4.49 × 10−3 | 2.80 | 0.77 | 15.97 | 16.23 |
| 15 | l-Threonine | 1.42 | 2.06 × 10−3 | 1.50 × 10−2 | 0.20 | 0.69 | 15.86 | 14.93 |
| 16 | Nonadecanoic acid | 1.41 | 8.80 × 10−4 | 8.42 × 10−3 | 2.36 | 0.83 | 24.46 | 26.66 |
| 17 | l-Threitol | 1.40 | 3.58 × 10−4 | 3.92 × 10−3 | 2.24 | 0.81 | 26.32 | 27.39 |
| 18 | d-Glucopyranose | 1.39 | 3.00 × 10−3 | 2.00 × 10−2 | 2.39 | 0.81 | 22.71 | 25.80 |
| 19 | 2-Alpha-mannobiose | 1.38 | 5.87 × 10−3 | 3.10 × 10−2 | 1.50 | 0.73 | 27.28 | 29.84 |
| 20 | Cystathionine | 1.33 | 3.51 × 10−3 | 2.07 × 10−2 | 0.63 | 0.80 | 23.40 | 14.67 |
| 21 | Stearate | 1.27 | 2.82 × 10−3 | 1.96 × 10−2 | 2.11 | 0.87 | 15.82 | 13.26 |
| 22 | Inositol | 1.25 | 1.42 × 10−3 | 1.15 × 10−2 | 1.54 | 0.80 | 18.54 | 19.23 |
| 23 | l-Asparagine | 1.20 | 1.94 × 10−3 | 1.48 × 10−2 | 0.49 | 0.85 | 25.63 | 27.52 |
| 24 | Arachidonic acid | 1.20 | 1.13 × 10−2 | 4.93 × 10−2 | 1.60 | 0.71 | 16.92 | 20.84 |
| 25 | Beta-d-galactofuranose | 1.19 | 7.39 × 10−3 | 3.54 × 10−2 | 2.04 | 0.84 | 24.36 | 19.56 |
| 26 | d-Xylopyranose | 1.18 | 1.31 × 10−3 | 1.15 × 10−2 | 0.23 | 0.79 | 25.87 | 27.32 |
| 27 | Stigmasterol | 1.18 | 1.38 × 10−3 | 1.15 × 10−2 | 0.54 | 0.80 | 28.39 | 27.65 |
| 28 | Maltitol | 1.10 | 7.65 × 10−3 | 3.55 × 10−2 | 3.51 | 0.74 | 26.57 | 28.34 |