One-pot synthesis of β-hydroxy-1,2,3-triazoles from epoxides catalyzed by nano-CoFe2O4/Cu(OH)2a.
Entry | Epoxide (a) | Alkyne | Triazole (b) | Time (h) | Yieldb (%) |
---|---|---|---|---|---|
1 |
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3.3 | 94 |
2 |
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3 | 95 |
3 |
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3.3 | 90 |
4 |
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4.3 | 88 |
5 |
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4.5 | 85 |
6 |
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4.5 | 87 |
7 |
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5.5 | 75 |
8 |
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4.3 | 80 |
9 |
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4.2 | 85 |
10 |
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6.3 | 84 |
11 |
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5 | 82 |
12 |
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6 | 85 |
13 |
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6 | 87 |
14 |
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6.5 | 88 |
15 |
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5 | 80 |
16 |
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5 | 90 |
17 |
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6 | 92 |
18 |
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5.5 | 85 |
19 |
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4 | 90 |
20 |
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5 | 88 |
21 |
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6.5 | 84 |
All reactions were carried out with 1 mmol of epoxide in the presence of alkyne (1 mmol), sodium azide (1.2 mmol) and nano-CoFe2O4/Cu(OH)2 (0.032 g, 0.1 mmol, 10 mol%) in water at 60 °C.
Yields refer to isolated pure products.