Predicted blood–brain barrier permeation and human intestinal absorption obtained using the PreADME application.

System	MW	log P	log D	pKa	pTSA (Å2)	mPO	log(BBB)	HIA (%)
1	344.44	2.25	2.11	7.33	60.35	5.44	−1.38	94.72
1_1	332.42	2.91	2.80	7.08	61.21	5.43	−0.24	90.74
1_2	315.38	2.12	1.98	7.86	77.00	5.50	−0.40	89.30
1_3	344.43	3.02	2.92	7.07	51.21	5.36	−1.24	97.15
1_4	329.36	2.17	2.10	7.07	87.25	5.78	−1.13	95.94
3_1	372.47	1.33	0.96	8.79	85.26	5.02	−1.44	94.27
3_3	357.46	0.43	0.56	8.49	99.48	4.44	−1.17	84.95
CNS drugs	<450	<5	1–4	<10	<90	>4	−2 to 1