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| ||||
|---|---|---|---|---|
| Compd | R | IC50a (μM) | ||
| A549 | MCF-7 | HePG2 | ||
| 4a | 4-H | >100 | >100 | >100 |
| 4b | 4-CH3 | >100 | >100 | >100 |
| 4c | 4-F | >100 | >100 | >100 |
| 4d | 4-Cl | >100 | >100 | >100 |
| 7a | 4-H | 37.62 ± 1.88 | 25.30 ± 0.93 | 20.16 ± 1.15 |
| 7b | 4-CH3 | 35.04 ± 0.97 | 30.95 ± 1.05 | 33.94 ± 1.13 |
| 7c | 4-F | >100 | >100 | >100 |
| 7d | 4-Cl | >100 | >100 | >100 |
| GDC-0941b | — | 6.99 ± 0.21 | 0.07 ± 0.03 | 0.20 ± 0.08 |
The values are an average of two separate determinations.
Used as a positive controls.
