In vitro cell viability of target compound 13a–l.
| |||||
|---|---|---|---|---|---|
| Compd | R 1 | R 2 | IC50a (μM) | ||
| A549 | MCF-7 | HepG2 | |||
| 13a | 4-OCH3 | 3,4-Di Cl | NA | NA | NA |
| 13b | 4-Br | 3,4-Di Cl | 17.43 ± 0.13 | 12.82 ± 0.23 | 12.90 ± 0.64 |
| 13c | 4-F | 4-F | 9.23 ± 0.02 | 6.51 ± 0.31 | 6.66 ± 0.13 |
| 13d | 4-F | 3,4-Di Cl | 9.17 ± 0.32 | 6.82 ± 0.17 | 7.27 ± 0.68 |
| 13e | 4-H | 3,4-Di Cl | 13.41 ± 0.29 | 10.48 ± 0.54 | 8.05 ± 0.05 |
| 13f | 4-OCH3 | 4-H | 2.84 ± 0.09 | 2.88 ± 0.43 | 2.08 ± 0.36 |
| 13g | 4-CH3 | 3,4-Di Cl | 8.75 ± 0.24 | 4.98 ± 0.04 | 6.96 ± 0.44 |
| 13h | 4-CH3 | 4-Br | 5.43 ± 0.17 | NA | 4.45 ± 0.25 |
| 13i | 4-H | 4-H | 9.43 ± 0.10 | 5.04 ± 0.06 | 6.70 ± 0.14 |
| 13j | 4-OCH3 | 4-F | NA | NA | 83.86 ± 0.17 |
| 13k | 4-F | 4-Br | 22.65 ± 0.35 | 18.39 ± 0.18 | 10.89 ± 0.20 |
| 13l | 4-H | 4-Br | 22.95 ± 0.15 | 17.17 ± 0.48 | 15.79 ± 1.23 |
| GDC-0941b | — | — | 6.99 ± 0.21 | 0.20 ± 0.08 | 0.07 ± 0.03 |
a
The values are an average of two separate determinations.
b
Used as a positive controls.