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| Compd | IC50a (μM) | |
|---|---|---|
| PI3Kαc | mTORd | |
| 13c | 4.62 ± 0.54 | >10 |
| 13f | 0.92 ± 0.14 | >10 |
| 13g | 3.31 ± 0.12 | >10 |
| 13h | 7.16 ± 0.27 | >10 |
| GDC-0941b | 0.003 | 0.58 |
The values are an average of two separate determinations.
Used as a positive controls.
PI3Kα: phosphatidylinositol-3-kinase alpha subunit.
mTOR: mammalian target of rapamycin.
