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. 2019 Sep 24;9(52):30087–30099. doi: 10.1039/c9ra05712a

Antifungal activity of 8-hydroxyquinoline derivatives at 50, 25 μg mL−1.

Compd.a Concb (μg mL−1) Average inhibition rate ± SD (%) (n = 3)
B. C. c S. S. c F. G. c F. O. c M. O. c
HQ 50 100.00 ± 0.00 100.00 ± 0.00 100.00 ± 0.00 73.01 ± 0.33 100.00 ± 0.00
25 100.00 ± 0.00 100.00 ± 0.00 77.19 ± 0.31 36.29 ± 0.67 100.00 ± 0.00
2 50 100.00 ± 0.00 100.00 ± 0.00 100.00 ± 0.00 100.00 ± 0.00 100.00 ± 0.00
25 100.00 ± 0.00 100.00 ± 0.00 100.00 ± 0.00 100.00 ± 0.00 100.00 ± 0.00
4a 50 97.92 ± 0.72 100.00 ± 0.00 0.00 ± 0.00 36.00 ± 0.74 31.56 ± 0.72
25 85.39 ± 0.65 100.00 ± 0.00 0.00 ± 0.00 24.89 ± 0.72 11.11 ± 0.72
4b 50 100.00 ± 0.00 100.00 ± 0.00 85.00 ± 0.01 93.78 ± 0.72 100.00 ± 0.00
25 98.33 ± 0.72 86.04 ± 0.97 78.75 ± 0.01 79.56 ± 0.72 74.44 ± 0.95
4c 50 100.00 ± 0.00 100.00 ± 0.00 0.00 ± 0.00 25.78 ± 0.72 35.56 ± 0.72
25 93.00 ± 0.41 97.92 ± 0.72 0.00 ± 0.00 16.44 ± 0.72 17.56 ± 0.95
4d 50 100.00 ± 0.00 100.00 ± 0.00 12.92 ± 0.01 28.44 ± 0.44 27.11 ± 0.34
25 85.08 ± 0.49 89.80 ± 0.49 0.00 ± 0.00 15.33 ± 0.63 12.44 ± 0.72
4e 50 26.31 ± 0.19 0.00 ± 0.00 47.50 ± 0.02 31.25 ± 0.02 27.11 ± 0.07
25 29.71 ± 0.16 0.00 ± 0.00 19.17 ± 0.02 14.89 ± 0.95 11.56 ± 0.72
4f 50 100.00 ± 0.00 100.00 ± 0.00 0.00 ± 0.00 33.73 ± 0.25 40.44 ± 0.72
25 97.24 ± 0.01 97.92 ± 0.72 0.00 ± 0.00 16.67 ± 0.62 33.78 ± 0.72
4g 50 100.00 ± 0.00 100.00 ± 0.00 0.00 ± 0.00 20.00 ± 0.36 18.67 ± 0.17
25 100.00 ± 0.00 100.00 ± 0.00 0.00 ± 0.00 13.76 ± 0.74 0.00 ± 0.00
4h 50 100.00 ± 0.00 100.00 ± 0.00 0.00 ± 0.00 18.22 ± 0.60 29.78 ± 0.15
25 100.00 ± 0.00 100.00 ± 0.00 0.00 ± 0.00 4.89 ± 0.72 11.11 ± 0.72
4i 50 100.00 ± 0.00 100.00 ± 0.00 10.42 ± 0.01 43.11 ± 0.91 32.44 ± 0.60
25 100.00 ± 0.00 100.00 ± 0.00 0.00 ± 0.00 19.99 ± 0.01 20.89 ± 0.72
4j 50 100.00 ± 0.00 100.00 ± 0.00 18.33 ± 0.01 44.89 ± 0.72 28.89 ± 0.91
25 99.58 ± 0.72 100.00 ± 0.00 0.00 ± 0.00 26.00 ± 0.62 16.22 ± 0.36
4k 50 100.00 ± 0.00 100.00 ± 0.00 00.00 ± 0.00 32.89 ± 0.72 27.56 ± 0.60
25 97.88 ± 0.31 100.00 ± 0.00 0.00 ± 0.00 23.02 ± 0.80 17.78 ± 0.72
4l 50 100.00 ± 0.00 100.00 ± 0.00 93.33 ± 0.01 78.67 ± 0.05 34.67 ± 0.25
25 100.00 ± 0.00 100.00 ± 0.00 0.00 ± 0.00 43.56 ± 0.72 20.53 ± 0.66
4m 50 99.58 ± 0.72 100.00 ± 0.00 21.67 ± 0.03 75.56 ± 0.91 47.56 ± 0.60
25 77.14 ± 0.74 97.92 ± 0.72 12.50 ± 0.03 52.67 ± 0.62 41.96 ± 0.63
4n 50 100.00 ± 0.00 100.00 ± 0.00 28.75 ± 0.03 36.00 ± 0.25 36.89 ± 0.72
25 98.33 ± 0.72 100.00 ± 0.00 3.33 ± 0.03 19.56 ± 0.72 25.78 ± 0.72
4o 50 100.00 ± 0.00 100.00 ± 0.00 0.00 ± 0.00 32.89 ± 0.72 33.78 ± 0.91
25 98.33 ± 0.72 100.00 ± 0.00 0.00 ± 0.00 18.22 ± 0.72 27.08 ± 0.75
5a 50 52.33 ± 0.86 0.00 ± 0.00 9.58 ± 0.03 20.89 ± 0.44 48.89 ± 0.73
25 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 38.22 ± 0.72
5b 50 99.11 ± 0.09 99.14 ± 0.07 97.92 ± 0.01 100.00 ± 0.00 100.00 ± 0.00
25 97.92 ± 0.18 97.25 ± 0.77 93.79 ± 0.01 100.00 ± 0.00 100.00 ± 0.00
5c 50 100.00 ± 0.00 100.00 ± 0.00 95.42 ± 0.01 100.00 ± 0.00 100.00 ± 0.00
25 100.00 ± 0.00 100.00 ± 0.00 92.79 ± 0.01 100.00 ± 0.00 98.17 ± 0.48
5d 50 100.00 ± 0.00 100.00 ± 0.00 94.17 ± 0.03 100.00 ± 0.00 100.00 ± 0.00
25 100.00 ± 0.00 100.00 ± 0.00 85.21 ± 0.01 100.00 ± 0.00 100.00 ± 0.00
5e 50 100.00 ± 0.00 100.00 ± 0.00 16.67 ± 0.02 44.89 ± 0.60 66.22 ± 0.61
25 100.00 ± 0.00 100.00 ± 0.00 7.08 ± 0.01 34.09 ± 0.64 59.11 ± 0.72
5f 50 100.00 ± 0.00 100.00 ± 0.00 99.17 ± 0.01 100.00 ± 0.00 84.00 ± 0.03
25 100.00 ± 0.00 100.00 ± 0.00 88.24 ± 0.01 80.34 ± 0.82 80.69 ± 0.73
5g 50 100.00 ± 0.00 100.00 ± 0.00 98.75 ± 0.01 99.56 ± 0.72 100.00 ± 0.00
25 100.00 ± 0.00 100.00 ± 0.00 91.27 ± 0.00 75.96 ± 0.69 98.88 ± 0.60
5h 50 97.85 ± 0.08 100.00 ± 0.00 98.33 ± 0.01 100.00 ± 0.00 100.00 ± 0.00
25 90.68 ± 0.73 91.06 ± 0.39 88.86 ± 0.02 95.94 ± 0.16 100.00 ± 0.00
5i 50 97.92 ± 0.72 100.00 ± 0.00 100.00 ± 0.00 100.00 ± 0.00 100.00 ± 0.00
25 97.91 ± 0.39 100.00 ± 0.00 89.50 ± 0.00 100.00 ± 0.00 100.00 ± 0.00
5j 50 100.00 ± 0.00 100.00 ± 0.00 99.17 ± 0.01 100.00 ± 0.00 100.00 ± 0.00
25 100.00 ± 0.00 97.92 ± 0.72 80.87 ± 0.02 100.00 ± 0.00 100.00 ± 0.00
5k 50 100.00 ± 0.00 100.00 ± 0.00 97.85 ± 0.05 60.00 ± 0.17 44.89 ± 0.44
25 98.33 ± 0.72 100.00 ± 0.00 57.08 ± 0.01 32.89 ± 0.72 31.16 ± 0.69
5l 50 100.00 ± 0.00 100.00 ± 0.00 93.75 ± 0.01 100.00 ± 0.70 99.13 ± 0.41
25 95.78 ± 0.12 100.00 ± 0.00 91.21 ± 0.00 97.67 ± 0.93 94.92 ± 0.65
5m 50 83.11 ± 0.70 93.03 ± 0.80 34.58 ± 0.03 86.67 ± 0.17 83.11 ± 0.72
25 86.46 ± 0.53 91.63 ± 0.53 23.33 ± 0.02 79.16 ± 0.79 76.67 ± 0.63
5n 50 88.66 ± 0.39 100.00 ± 0.00 48.33 ± 0.02 73.75 ± 0.50 63.56 ± 0.91
25 81.50 ± 0.36 97.36 ± 0.92 24.17 ± 0.05 0.00 ± 0.00 55.11 ± 0.72
5o 50 87.00 ± 0.00 90.55 ± 0.00 39.17 ± 0.01 37.78 ± 0.72 32.89 ± 0.52
25 85.82 ± 0.81 77.30 ± 0.23 4.17 ± 0.02 28.75 ± 0.72 23.33 ± 0.62
5p 50 100.00 ± 0.00 100.00 ± 0.00 73.75 ± 0.01 54.67 ± 0.25 31.56 ± 0.71
25 100.00 ± 0.00 100.00 ± 0.00 44.17 ± 0.02 41.62 ± 0.83 23.33 ± 0.62
5q 50 100.00 ± 0.00 100.00 ± 0.00 11.25 ± 0.03 47.56 ± 0.72 34.22 ± 0.60
25 98.33 ± 0.72 98.13 ± 0.63 0.00 ± 0.00 43.56 ± 0.72 20.44 ± 0.72
ASBd 50 47.88 ± 0.43 45.57 ± 0.29 61.85 ± 0.06 36.42 ± 0.43 33.31 ± 0.25
25 27.00 ± 0.23 30.43 ± 0.98 57.32 ± 0.28 31.87 ± 0.61 29.49 ± 0.70
a

Compd.: compound.

b

Conc: concentration.

c

B. C.: Botrytis cinerea. S. S.: Sclerotinia sclerotiorum. F. G.: Fusarium graminearum. F. O.: Fusarium oxysporum. f. sp. vasinfectum. M. O.: Magnaporthe oryzae.

d

ASB: azoxystrobin.