Table 2.
Pharmacokinetic parameters obtained after oral administration of DOX and DOX@CMSs in SD rats.
| Parameter | DOX | DOX@CMSSs | DOX@CMSRs | DOX@CMSWs |
|---|---|---|---|---|
| AUC0‒∞ (mg/L·h) | 4.00 ± 0.02 | 5.57 ± 1.63 | 11.03 ± 1.18 | 13.94 ± 0.56 |
| MRT0‒∞ (h) | 24.58 ± 0.34 | 16.84 ± 2.36 | 34.28 ± 6.18 | 29.73 ± 0.66 |
| t1/2 (h) | 12.62 ± 0.58 | 5.87 ± 2.19 | 16.60 ± 4.16 | 11.04 ± 0.48 |
| Tmax (h) | 1.00 | 13.33 ± 12.70 | 24.00 | 28.00 |
| Cmax (mg/L) | 0.16 ± 0.01 | 0.23 ± 0.04 | 0.29 ± 0.01 | 0.57 ± 0.04 |
| Frel (%) | 100 | 139 | 276 | 348 |
Data are expressed as mean ± SD (n = 3). AUC0‒∞, area under the curve; Cmax, maximum concentration; Frel, relative bioavailability; MRT0-∞, mean residence time; t1/2, half-life; Tmax, peak time.