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. 2021 Aug 14;12(3):1288–1304. doi: 10.1016/j.apsb.2021.08.015

Figure 7.

Figure 7

Z-GP-DABLBH suppresses the outgrowth of xenografted osteosarcoma cells in BALB/c nude mice. (A) and (B) BALB/c nude mice bearing SJSA-1 or 143B tumors were treated with vehicle (0.9% NaCl solution containing 1% DMSO) or Z-GP-DAVLBH (2 mg/kg, i.v.) every other day. The tumor volumes of tumor-bearing mice were measured every other day. (A, right) The weights of SJSA-1 and 143B tumors is shown. Representative images of tumors are shown. Scale bar: 1 cm. (B) The body weights of tumor bearing mice were measured every other day. (C) IHC staining of Ki67 and cleaved caspase-3 and immunofluorescence staining of p-histone H3 (Ser 10) in SJSA-1 and 143B xenograft tumors. Scale bar: 100 μm for IF images or 200 μm for IHC images. (D) Quantification of IHC and IF staining in tumor tissues. Data are presented as mean±SEM, n = 6 or 7; ∗P<0.05, ∗∗P<0.01, and ∗∗∗P<0.001 vs. the Vehicle group.