Table 6. Cannabinoids for acne and skin rejuvenation.

CBD, cannabidiol.

Skin condition or restoration	Comments	Reference
Acne	CBD can exert anti-inflammatory, anti-microbial, and anti-lipogenic activity in human sebocytes in vitro. In a study of 11 Asian men, 3% cannabis seeds extract cream applied to the cheek twice daily for 12 weeks was associated with a statistically significant decrease in erythema and sebum compared to a base cream	[3]
Skin rejuvenation	Cannabinoids play a role in mediating the proliferation, differentiation, and survival of basal cells in the epidermis. Hemp seed hexane extracts can stimulate collagen synthesis in vitro	[3]