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Effect of delayed treatment with RWJ-270201 or oseltamivir on survival rates of mice infected with A/HK/156/97 (H5N1) influenza virus. BALB/c mice (n = 9 to 10 per group) were infected intranasally with 10 MLD50s of influenza A/HK/156/97 (H5N1) virus and treated with RWJ-270201 or oseltamivir at 10 mg/kg/day by twice-daily oral gavage for 5 days. Treatment began 24 (▪), 36 (○), 48 (▴), or 60 (⧫) hours after virus inoculation. Control untreated animals (□) received PBS.
